With an increasing defect size the pace of bone regeneration decreases, since the regeneration process is not based on a linear reaction. Therefore, please note that the defects with a maximum volume of less than 1.5 cm require three months, defects with a size between 1.5 cm and 2.5 cm six months, and defects of more than 2.5 cm nine months for complete bony regeneration.

Note
Bioresorb Macro Pore should be used only by a dentist or physician who is familiar with oral implantology and augmentation techniques. It is recommended to use Bioresorb Macro Pore in a moist state. The mass of the individual granules adheres and allows an easier application into the defect than in dry state. For moistening, a sterile isotonic saline solution can be used, or autogenous blood of the patient or blood plasma (PRP – platelet rich plasma). If there is a risk of infection, combine with antibiotics. If the defect is larger than 2 cm, we recommend to use a mixture of Bioresorb Macro Pore with autogenous bone if harvesting is anatomically possible.

When applying the material, do not compress to save the interconnecting porosity, but spread evenly in the defect and fill completely. The granule sizes to be used is depending on the size of the defect. In general, the larger the defect, the larger the
granule size. Once the bone defect has been densely filled up to the edges by using a spoon or spatula – depending on the size – the site is closed using the usual suture technique. The covering gingiva periost flap should achieve primary closure without tension so that no granules can be washed out. If primary closure is not possible, we recommend the use of a non-resorbably membrane Cytoplast Non Resorb, according to the situation and following the instructions for use for membrane technique. The augmented site should not be loaded during the initial healing phase (i.e. do not use temporary prostheses or bridges on temporary implants, etc.).